Explanation of classes
Class A
Soluble, intracellular, no signal-peptide/no transmembrane domain
- There was no ER retention signal peptide predicted in this sequence
- There was no alpha-helical transmembrane domain predicted in this sequence
- This sequence is predicted to be soluble and intracellular
Class B
Soluble, secreted, signal-peptide/no transmembrane domain
- There was an ER retention signal peptide predicted in this sequence
- There was no alpha-helical transmembrane domain predicted in this sequence
- This sequence is predicted to be secreted from the cell
- WARNING - alpha-helical transmembrane domains can be mispredicted as signal peptides
Class C
Type I membrane protein, signal-peptide/one transmembrane domain
- There was an ER retention signal peptide predicted in this sequence
- There was one alpha-helical transmembrane domain predicted in this sequence
- This sequence is predicted to be a type I membrane protein (N-term out, C-term in)
- WARNING - alpha-helical transmembrane domains can be mispredicted as signal peptides
- WARNING - ER retention signal peptides can be mispredicted as alpha-helical transmembrane domains
Class D
Type II membrane protein, no signal-peptide/one transmembrane domain
- There was no ER retention signal peptide predicted in this sequence
- There was one alpha-helical transmembrane domain predicted in this sequence
- This sequence is predicted to be a type II membrane protein (N-term in, C-term out)
- WARNING - ER retention signal peptides can be mispredicted as alpha-helical transmembrane domains
Class E
Multispan membrane protein, >1 transmembrane domain
- There may or may not be an ER retention signal peptide predicted in this sequence
- There was more than one alpha-helical transmembrane domain predicted in this sequence
- This sequence is predicted to be a type I membrane protein (N-term out, C-term in)
- WARNING - alpha-helical transmembrane domains can be mispredicted as signal peptides
- WARNING - ER retention signal peptides can be mispredicted as alpha-helical transmembrane domains
Class F
Unclassified due to prediction conflict
- There was no clear consensus in the predictions for signal peptide and/or transmembrane domains in this sequence
Last Modified: Thursday, 08-Jan-2004 16:47:35 EST